Meeras marriage was arranged at an early age, traditionally to Prince Bhoj Raj, the eldest son of Rana Sanga of Chittor. She was not happy with her marriage as she considered herself already married to Krishna. Her new family did not approve of her piety and devotion when she refused to worship their family deity- Shiva. The Rajputana had remained fiercely independent of the Delhi Sultanate, the Islamic regime that otherwise ruled Hindustan after the conquests of Timur. But in the early 16th century AD the central Asian conqueror Babur laid claim to the Sultanate and some Rajputs supported him while others ended their lives in battle with him. Her husbands death in battle (in 1527 AD) was only one of a series of losses Meera experienced in her twenties. She appears to have despaired of loving anything temporal and turned to the eternal, transforming her grief into a passionate spiritual devotion that inspired in her countless songs drenched with separation and longing. Meeras love to Krishna was at first a private thing but at some moment it overflowed into an ecstasy that led her to dance in the streets of the city. Her brother-in-law, the new ruler of Chittorgarh, was Vikramaditya, an ill-natured youth who strongly objected to Meeras fame, her mixing with commoners and carelessness of feminine modesty. There were several attempts to poison her. Her sister-in-law Udabai is said to have spread defamatory gossip. According to some myths Meeras brother-in-law Vikramaditya, who later became king of Chittor, after Bhojrajs death, tried to harm Meera in many ways, such as:The famous one is that he mixed poison in the Prasadam or chandanamritam of Krishna and made her drink it. But by Gods grace, Krishna changed it to Amrit.He pinned iron nails in Meeras bed, but, again by Gods grace they turned into rose petals.He put a snake in a flower basket and told her that it was a gift from him to her Lord, but when she opened it it actually became a gift- a garland. There are many more in a similar vein.
At some time Meera declared herself a disciple of the guru Ravidas (guru miliyaa raidasjee) and left for the centre of Krishnaism, Vrindavan. She considered herself to be a reborn gopi, Lalita, mad with love for Krishna. Folklore informs us of a particular incident where she expressed her desire to engage in a discussion about spiritual matters with Rupa Goswami, a direct disciple of Chaitanya and one of the foremost saint of Vrindavan that time who, being a renunciate celibate, refused to meet a woman. Meera replied that the only true man (purusha) in this universe is Lord Krishna. She continued her pilgrimage, danced from one village to another village, almost covering the whole north of India. One story has her appearing in the company of Kabir in Kashi, once again causing affront to social mores. She seems to have spent her last years as a pilgrim in Dwarka, Gujarat. It is said that Mirabai disappeared into the Dwarkadhish Murti (Image of Lord Krishna) in front of a full audience of onlookers.